MYC drives Group 3 medulloblastoma through transformation of Sox2(+) astrocyte progenitor cells

A subset of Group 3 medulloblastoma frequently harbors amplification or overexpression of MYC lacking additional focal aberrations, yet it remains unclear whether MYC overexpression alone can induce tumorigenesis and which cells give rise to these tumors. Here, we showed that astrocyte progenitors i...

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Detaylı Bibliyografya
Yayımlandı:Cancer Res
Asıl Yazarlar: Tao, Ran, Murad, Najiba, Xu, Zhenhua, Zhang, Peng, Okonechnikov, Konstantin, Kool, Marcel, Rivero-Hinojosa, Samuel, Lazarski, Christopher, Zheng, Pan, Liu, Yang, Eberhart, Charles G., Rood, Brian R., Packer, Roger, Pei, Yanxin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6467710/
https://ncbi.nlm.nih.gov/pubmed/30862721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-1787
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