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Phosphorylation of the glucocorticoid receptor alters Smad signaling in vocal fold fibroblasts

OBJECTIVES/HYPOTHESIS. Direct glucocorticoid (GC) injection for vocal fold (VF) scarring has evolved as a therapeutic strategy, but the mechanisms underlying the anti-fibrotic effects remain unclear. GCs act via the glucocorticoid receptor (GR), which is phosphorylated at multiple serine residues in...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Laryngoscope
Hauptverfasser: Mukudai, Shigeyuki, Hiwatashi, Nao, Bing, Renjie, Garabedian, Michael, Branski, Ryan C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6467698/
https://ncbi.nlm.nih.gov/pubmed/30325506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/lary.27570
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