Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala

Oxytocin administration has been reported to decrease consumption, withdrawal, and drug-seeking associated with several drugs of abuse and thus represents a promising pharmacological approach to treat drug addiction. We used an established rat model of alcohol dependence to investigate oxytocin’s ef...

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Veröffentlicht in:PLoS Biol
Hauptverfasser: Tunstall, Brendan J., Kirson, Dean, Zallar, Lia J., McConnell, Sam A., Vendruscolo, Janaina C. M., Ho, Chelsea P., Oleata, Christopher S., Khom, Sophia, Manning, Maurice, Lee, Mary R., Leggio, Lorenzo, Koob, George F., Roberto, Marisa, Vendruscolo, Leandro F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2019
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6467366/
https://ncbi.nlm.nih.gov/pubmed/30990816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2006421
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