Caspase-3 Substrates for Noninvasive Pharmacodynamic Imaging of Apoptosis by PET/CT

Quantitative imaging of apoptosis in vivo could enable real-time monitoring of acute cell death pathologies such as traumatic brain injury, as well as the efficacy and safety of cancer therapy. Here, we describe the development and validation of F-18-labeled caspase-3 substrates for PET/CT imaging o...

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Detalhes bibliográficos
Publicado no:Bioconjug Chem
Main Authors: Engel, Brian J., Gammon, Seth T., Chaudhari, Rajan, Lu, Zhen, Pisaneschi, Federica, Yang, Hailing, Ornelas, Argentina, Yan, Victoria, Kelderhouse, Lindsay, Najjar, Amer M., Tong, William P., Zhang, Shuxing, Piwnica-Worms, David, Bast, Robert C., Millward, Steven W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6467260/
https://ncbi.nlm.nih.gov/pubmed/30168713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.8b00514
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