Automated, Resin-Based Method to Enhance the Specific Activity of Fluorine-18 Clicked PET Radiotracers

Radiolabeling of substrates with 2-[(18)F]-fluoroethylazide exploits the rapid kinetics, chemical selectivity, and mild conditions of the copper-catalyzed azide–alkyne cycloaddition reaction. While this methodology has proven to result in near-quantitative labeling of alkyne-tagged precursors, the r...

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Detalhes bibliográficos
Publicado no:Bioconjug Chem
Main Authors: Pisaneschi, Federica, Kelderhouse, Lindsay E., Hardy, Amanda, Engel, Brian J., Mukhopadhyay, Uday, Gonzalez-Lepera, Carlos, Gray, Joshua P., Ornelas, Argentina, Takahashi, Terry T., Roberts, Richard W., Fiacco, Stephen V., Piwnica-Worms, David, Millward, Steven W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6463876/
https://ncbi.nlm.nih.gov/pubmed/28150941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.6b00678
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