Directed Evolution of Scanning Unnatural Protease Resistant (SUPR) Peptides for In Vivo Applications

Peptides typically have poor biostabilities and natural sequences cannot easily be converted into drug-like molecules without extensive medicinal chemistry. We have adapted mRNA display to evolve highly stable cyclic peptides while preserving target affinity. To do this, we incorporated an unnatural...

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Bibliografiske detaljer
Udgivet i:Chembiochem
Main Authors: Fiacco, Stephen V., Kelderhouse, Lindsay E., Hardy, Amanda, Peleg, Yonatan, Hu, Biliang, Ornelas, Argentina, Yang, Peiying, Gammon, Seth, Howell, Shannon M., Wang, Pin, Takahashi, Terry T., Millward, Steven W., Roberts, Richard W.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5167532/
https://ncbi.nlm.nih.gov/pubmed/27465925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201600253
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