Directed Evolution of Scanning Unnatural Protease Resistant (SUPR) Peptides for In Vivo Applications

Peptides typically have poor biostabilities and natural sequences cannot easily be converted into drug-like molecules without extensive medicinal chemistry. We have adapted mRNA display to evolve highly stable cyclic peptides while preserving target affinity. To do this, we incorporated an unnatural...

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Detalhes bibliográficos
Publicado no:Chembiochem
Main Authors: Fiacco, Stephen V., Kelderhouse, Lindsay E., Hardy, Amanda, Peleg, Yonatan, Hu, Biliang, Ornelas, Argentina, Yang, Peiying, Gammon, Seth, Howell, Shannon M., Wang, Pin, Takahashi, Terry T., Millward, Steven W., Roberts, Richard W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5167532/
https://ncbi.nlm.nih.gov/pubmed/27465925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201600253
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