Exploiting Chemical Toolboxes for the Expedited Generation of Tetracyclic Quinolines as a Novel Class of PXR Agonists

[Image: see text] The discovery of lead compounds relies on the iterative generation of structure–activity relationship data resulting from the synthesis and biological evaluation of hit analogues. Using traditional approaches, a significant time delay may occur from compound design to results, lead...

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Publicado en:ACS Med Chem Lett
Autores principales: Cerra, Bruno, Carotti, Andrea, Passeri, Daniela, Sardella, Roccaldo, Moroni, Giada, Di Michele, Alessandro, Macchiarulo, Antonio, Pellicciari, Roberto, Gioiello, Antimo
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2018
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6466813/
https://ncbi.nlm.nih.gov/pubmed/30996817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00459
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