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An efficient synthesis of the guaiane sesquiterpene (−)-isoguaiene by domino metathesis

(−)-Isoguaiene was prepared from (S)-citronellal in only 9–10 steps with good overall yields. Either a trienyne or a dienediyne metathesis and highly diastereoselective organocatalytic Michael additions of aldehydes derived from (S)-citronellal served as the key transformations.

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Bibliografiske detaljer
Udgivet i:Beilstein J Org Chem
Main Authors: Wang, Yuzhou, Darweesh, Ahmed F, Zimdars, Patrick, Metz, Peter
Format: Artigo
Sprog:Inglês
Udgivet: Beilstein-Institut 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6466796/
https://ncbi.nlm.nih.gov/pubmed/31019578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.15.83
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