DNA methylation of TOMM40-APOE-APOC2 in Alzheimer’s disease

The apolipoprotein E (APOE) ε4 allele is the major genetic risk factor for Alzheimer’s disease (AD). Multiple regulatory elements, spanning the extended TOMM40-APOE-APOC2 region, regulate gene expression at this locus. Regulatory element DNA methylation changes occur under different environmental co...

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Pubblicato in:J Hum Genet
Autori principali: Shao, Yvonne, Shaw, McKenzie, Todd, Kaitlin, Khrestian, Maria, D’Aleo, Giana, Barnard, P. John, Zahratka, Jeff, Pillai, Jagan, Yu, Chang-En, Keene, C. Dirk, Leverenz, James B., Bekris, Lynn M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6466631/
https://ncbi.nlm.nih.gov/pubmed/29371683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s10038-017-0393-8
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