Synthesis and Evaluation of Bifunctional Aminothiazoles as Antiretrovirals Targeting the HIV-1 Nucleocapsid Protein

[Image: see text] Small molecule inhibitors of the HIV-1 nucleocapsid protein (NC) are considered as promising agents in the treatment of HIV/AIDS. In an effort to exploit the privileged 2-amino-4-phenylthiazole moiety in NC inhibition, here we conceived, synthesized, and tested in vitro 18 NC inhib...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Mori, Mattia, Dasso Lang, Maria Chiara, Saladini, Francesco, Palombi, Nastasja, Kovalenko, Lesia, De Forni, Davide, Poddesu, Barbara, Friggeri, Laura, Giannini, Alessia, Malancona, Savina, Summa, Vincenzo, Zazzi, Maurizio, Mely, Yves, Botta, Maurizio
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6466545/
https://ncbi.nlm.nih.gov/pubmed/30996780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00506
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