Novel Cyclic Biphalin Analogues by Ruthenium-Catalyzed Ring Closing Metathesis: in Vivo and in Vitro Biological Profile

[Image: see text] In this work we report the application of the ring-closing metathesis (RCM) to the preparation of two cyclic olefin-bridged analogues of biphalin (Tyr-d-Ala-Gly-Phe-NH-NH ← Phe ← Gly ← d-Ala ← Tyr), using the second generation Grubbs’ catalyst. The resulting cis- and trans-cyclic i...

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Bibliografske podrobnosti
izdano v:ACS Med Chem Lett
Main Authors: Stefanucci, Azzurra, Lei, Wei, Pieretti, Stefano, Dimmito, Marilisa Pia, Luisi, Grazia, Novellino, Ettore, Nowakowski, Michał, Koźmiński, Wiktor, Mirzaie, Sako, Zengin, Gokhan, Streicher, John M., Mollica, Adriano
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2019
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6466526/
https://ncbi.nlm.nih.gov/pubmed/30996778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00495
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