Design of N-Benzoxaborole Benzofuran GSK8175—Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor

[Image: see text] We previously described the discovery of GSK5852 (1), a non-nucleoside polymerase (NS5B) inhibitor of hepatitis C virus (HCV), in which an N-benzyl boronic acid was essential for potent antiviral activity. Unfortunately, facile benzylic oxidation resulted in a short plasma half-lif...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:J Med Chem
मुख्य लेखकों: Chong, Pek Y., Shotwell, J. Brad, Miller, John, Price, Daniel J., Maynard, Andy, Voitenleitner, Christian, Mathis, Amanda, Williams, Shawn, Pouliot, Jeffrey J., Creech, Katrina, Wang, Feng, Fang, Jing, Zhang, Huichang, Tai, Vincent W.-F., Turner, Elizabeth, Kahler, Kirsten M., Crosby, Renae, Peat, Andrew J.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Chemical Society 2019
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6466479/
https://ncbi.nlm.nih.gov/pubmed/30763090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01719
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