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The anticancer drug–DNA complex: Femtosecond primary dynamics for anthracycline antibiotics function

The anthracycline–DNA complex, which is a potent agent for cancer chemotherapy, has a unique intercalating molecular structure with preference to the GC bases of DNA, as shown by Rich's group in studies of single-crystal x-ray diffraction. Understanding cytotoxicity and its photoenhancement req...

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Autors principals: Qu, Xiaogang, Wan, Chaozhi, Becker, Hans-Christian, Zhong, Dongping, Zewail, Ahmed H.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2001
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC64661/
https://ncbi.nlm.nih.gov/pubmed/11724924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.241509698
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