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Interferon-Independent Upregulation of Interferon-Stimulated Genes during Human Cytomegalovirus Infection is Dependent on IRF3 Expression

The antiviral activity of type I interferons (IFNs) is primarily mediated by interferon-stimulated genes (ISGs). Induction of ISG transcription is achieved when type I IFNs bind to their cognate receptor and activate the Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) signal...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Viruses
Hauptverfasser: Ashley, Caroline L., Abendroth, Allison, McSharry, Brian P., Slobedman, Barry
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6466086/
https://ncbi.nlm.nih.gov/pubmed/30871003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v11030246
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