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Abrogation of the Interferon Response Promotes More Efficient Human Cytomegalovirus Replication

The effect of abrogating the interferon (IFN) response on human cytomegalovirus (HCMV) replication was investigated using primary human cells engineered to block either the production of or the response to type I IFNs. In IFN-deficient cells, HCMV produced larger plaques and spread and replicated mo...

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Detalles Bibliográficos
Publicado en:J Virol
Main Authors: McSharry, Brian P., Forbes, Simone K., Avdic, Selmir, Randall, Richard E., Wilkinson, Gavin W. G., Abendroth, Allison, Slobedman, Barry
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4300662/
https://ncbi.nlm.nih.gov/pubmed/25392213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02988-14
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