Abrogation of the Interferon Response Promotes More Efficient Human Cytomegalovirus Replication

The effect of abrogating the interferon (IFN) response on human cytomegalovirus (HCMV) replication was investigated using primary human cells engineered to block either the production of or the response to type I IFNs. In IFN-deficient cells, HCMV produced larger plaques and spread and replicated mo...

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Bibliografiset tiedot
Julkaisussa:J Virol
Päätekijät: McSharry, Brian P., Forbes, Simone K., Avdic, Selmir, Randall, Richard E., Wilkinson, Gavin W. G., Abendroth, Allison, Slobedman, Barry
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2014
Aiheet:
Virus-Cell Interactions
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4300662/
https://ncbi.nlm.nih.gov/pubmed/25392213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02988-14
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