A Single Conserved Amino Acid Residue as a Critical Context-Specific Determinant of the Differential Ability of Mdm2 and MdmX RING Domains to Dimerize

Mdm2 and MdmX are related proteins serving in the form of the Mdm2 homodimer or Mdm2/MdmX heterodimer as an E3 ubiquitin ligase for the tumor suppressor p53. The dimerization is required for the E3 activity and is mediated by the conserved RING domains present in both proteins, but only the RING dom...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Kosztyu, Pavlína, Slaninová, Iva, Valčíková, Barbora, Verlande, Amandine, Müller, Petr, Paleček, Jan J., Uldrijan, Stjepan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6465955/
https://ncbi.nlm.nih.gov/pubmed/31024344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2019.00390
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