Therapeutic targeting of BRCA1 and TP53 mutant breast cancer through mutant p53 reactivation

Triple negative breast cancer (TNBC) is an aggressive subset for which effective therapeutic approaches are needed. A significant proportion of TNBC patients harbor either germline or somatic mutations in BRCA1, or epigenetic silencing of BRCA1, which renders them deficient in DNA repair. Virtually...

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Bibliografiske detaljer
Udgivet i:NPJ Breast Cancer
Main Authors: Na, Bing, Yu, Xin, Withers, Tracy, Gilleran, John, Yao, Ming, Foo, Tzeh Keong, Chen, Chunxia, Moore, Dirk, Lin, Yong, Kimball, S. David, Xia, Bing, Ganesan, Shridar, Carpizo, Darren R.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6465291/
https://ncbi.nlm.nih.gov/pubmed/30993195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41523-019-0110-1
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