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IL-1 induces p62/SQSTM1 and autophagy in ERα(+)/PR(+) BCa cell lines concomitant with ERα and PR repression, conferring an ERα(−)/PR(−) BCa-like phenotype
Estrogen receptor alpha (ERα)(low/−) tumors are associated with breast cancer (BCa) endocrine resistance, where ERα low tumors show a poor prognosis and a molecular profile similar to triple negative BCa tumors. Interleukin-1 (IL-1) downregulates ERα accumulation in BCa cell lines, yet the cells can...
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| Udgivet i: | J Cell Biochem |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6465183/ https://ncbi.nlm.nih.gov/pubmed/30324661 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.27340 |
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