Electron-Mediated Aminyl and Iminyl Radicals from C5 Azido-Modified Pyrimidine Nucleosides Augment Radiation Damage to Cancer Cells

Two classes of azido-modified pyrimidine nucleosides were synthesized as potential radiosensitizers; one class is 5-azidomethyl-2′-deoxyuridine (AmdU) and cytidine (AmdC), while the second class is 5-(1-azidovinyl)-2′-deoxyuridine (AvdU) and cytidine (AvdC). The addition of radiation-produced electr...

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Detalhes bibliográficos
Publicado no:Org Lett
Main Authors: Wen, Zhiwei, Peng, Jufang, Tuttle, Paloma R., Ren, Yaou, Garcia, Carol, Debnath, Dipra, Rishi, Sunny, Hanson, Cameron, Ward, Samuel, Kumar, Anil, Liu, Yanfeng, Zhao, Weixi, Glazer, Peter M., Liu, Yuan, Sevilla, Michael D., Adhikary, Amitava, Wnuk, Stanislaw F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6465127/
https://ncbi.nlm.nih.gov/pubmed/30457873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.8b03035
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