Electron-Mediated Aminyl and Iminyl Radicals from C5 Azido-Modified Pyrimidine Nucleosides Augment Radiation Damage to Cancer Cells

Two classes of azido-modified pyrimidine nucleosides were synthesized as potential radiosensitizers; one class is 5-azidomethyl-2′-deoxyuridine (AmdU) and cytidine (AmdC), while the second class is 5-(1-azidovinyl)-2′-deoxyuridine (AvdU) and cytidine (AvdC). The addition of radiation-produced electr...

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Pubblicato in:Org Lett
Autori principali: Wen, Zhiwei, Peng, Jufang, Tuttle, Paloma R., Ren, Yaou, Garcia, Carol, Debnath, Dipra, Rishi, Sunny, Hanson, Cameron, Ward, Samuel, Kumar, Anil, Liu, Yanfeng, Zhao, Weixi, Glazer, Peter M., Liu, Yuan, Sevilla, Michael D., Adhikary, Amitava, Wnuk, Stanislaw F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6465127/
https://ncbi.nlm.nih.gov/pubmed/30457873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.8b03035
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