Electron-Mediated Aminyl and Iminyl Radicals from C5 Azido-Modified Pyrimidine Nucleosides Augment Radiation Damage to Cancer Cells

Two classes of azido-modified pyrimidine nucleosides were synthesized as potential radiosensitizers; one class is 5-azidomethyl-2′-deoxyuridine (AmdU) and cytidine (AmdC), while the second class is 5-(1-azidovinyl)-2′-deoxyuridine (AvdU) and cytidine (AvdC). The addition of radiation-produced electr...

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Bibliografski detalji
Izdano u:Org Lett
Glavni autori: Wen, Zhiwei, Peng, Jufang, Tuttle, Paloma R., Ren, Yaou, Garcia, Carol, Debnath, Dipra, Rishi, Sunny, Hanson, Cameron, Ward, Samuel, Kumar, Anil, Liu, Yanfeng, Zhao, Weixi, Glazer, Peter M., Liu, Yuan, Sevilla, Michael D., Adhikary, Amitava, Wnuk, Stanislaw F.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6465127/
https://ncbi.nlm.nih.gov/pubmed/30457873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.8b03035
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