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Reactions of Trimethylsilyl Fluorosulfonyldifluoroacetate with Purine and Pyrimidine Nucleosides

Difluorocarbene, generated from trimethylsilyl fluorosulfonyldifluoroacetate (TFDA), reacts with the uridine and adenosine substrates preferentially at the enolizable amide moiety of the uracil ring and the 6-amino group of the purine ring. 2',3'-Di-O-acetyl-3'-deoxy-3'-methylene...

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Detalhes bibliográficos
Main Authors: Rapp, Magdalena, Cai, Xiaohong, Xu, Wei, Dolbier, William R., Wnuk, Stanislaw F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663956/
https://ncbi.nlm.nih.gov/pubmed/20160856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jfluchem.2008.12.004
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