Abemaciclib Inhibits Renal Tubular Secretion Without Changing Glomerular Filtration Rate

Abemaciclib, an inhibitor of cyclin dependent kinases 4 and 6, is indicated for metastatic breast cancer treatment. Reversible increases in serum creatinine levels of ~15–40% over baseline have been observed following abemaciclib dosing. This study assessed the in vitro and clinical inhibition of re...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Clin Pharmacol Ther
Main Authors: Chappell, Jill C., Turner, P. Kellie, Pak, Y. Anne, Bacon, James, Chiang, Alan Y., Royalty, Jane, Hall, Stephen D., Kulanthaivel, Palaniappan, Bonventre, Joseph V.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6465099/
https://ncbi.nlm.nih.gov/pubmed/30449032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1296
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker