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Abemaciclib Inhibits Renal Tubular Secretion Without Changing Glomerular Filtration Rate
Abemaciclib, an inhibitor of cyclin dependent kinases 4 and 6, is indicated for metastatic breast cancer treatment. Reversible increases in serum creatinine levels of ~15–40% over baseline have been observed following abemaciclib dosing. This study assessed the in vitro and clinical inhibition of re...
שמור ב:
| הוצא לאור ב: | Clin Pharmacol Ther |
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| Main Authors: | , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
John Wiley and Sons Inc.
2018
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6465099/ https://ncbi.nlm.nih.gov/pubmed/30449032 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1296 |
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