Abemaciclib Inhibits Renal Tubular Secretion Without Changing Glomerular Filtration Rate

Abemaciclib, an inhibitor of cyclin dependent kinases 4 and 6, is indicated for metastatic breast cancer treatment. Reversible increases in serum creatinine levels of ~15–40% over baseline have been observed following abemaciclib dosing. This study assessed the in vitro and clinical inhibition of re...

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Bibliographische Detailangaben
Veröffentlicht in:Clin Pharmacol Ther
Hauptverfasser: Chappell, Jill C., Turner, P. Kellie, Pak, Y. Anne, Bacon, James, Chiang, Alan Y., Royalty, Jane, Hall, Stephen D., Kulanthaivel, Palaniappan, Bonventre, Joseph V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2018
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6465099/
https://ncbi.nlm.nih.gov/pubmed/30449032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1296
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