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Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis

Dysregulation of inflammatory cell death is a key driver of many inflammatory diseases. Pyroptosis, a highly inflammatory form of cell death, uses intracellularly generated pores to disrupt electrolyte homeostasis and execute cell death. Gasdermin D, the pore-forming effector protein of pyroptosis,...

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發表在:Sci Immunol
Main Authors: Rathkey, Joseph K., Zhao, Junjie, Liu, Zhonghua, Chen, Yinghua, Yang, Jie, Kondolf, Hannah C., Benson, Bryan L., Chirieleison, Steven M., Huang, Alex Y., Dubyak, George R., Xiao, Tsan S., Li, Xiaoxia, Abbott, Derek W.
格式: Artigo
語言:Inglês
出版: 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6462819/
https://ncbi.nlm.nih.gov/pubmed/30143556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aat2738
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