Stabilization of the V2 loop improves the presentation of V2 loop–associated broadly neutralizing antibody epitopes on HIV-1 envelope trimers

A successful HIV-1 vaccine will likely need to elicit broadly neutralizing antibodies (bNAbs) that target the envelope glycoprotein (Env) spike on the virus. Native-like recombinant Env trimers of the SOSIP design now serve as a platform for achieving this challenging goal. However, SOSIP trimers us...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: de Taeye, Steven W., Go, Eden P., Sliepen, Kwinten, de la Peña, Alba Torrents, Badal, Kimberly, Medina-Ramírez, Max, Lee, Wen-Hsin, Desaire, Heather, Wilson, Ian A., Moore, John P., Ward, Andrew B., Sanders, Rogier W.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Protein Structure and Folding
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6462529/
https://ncbi.nlm.nih.gov/pubmed/30728245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005396
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