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Histone deacetylase inhibitors induce complex host responses that contribute to differential potencies of these compounds in HIV reactivation
Histone deacetylase (HDAC) inhibitors (HDACis) have been widely tested in clinical trials for their ability to reverse HIV latency but have yielded only limited success. One HDACi, suberoylanilide hydroxamic acid (SAHA), exhibits off-target effects on host gene expression predicted to interfere with...
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| Publicado no: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6462528/ https://ncbi.nlm.nih.gov/pubmed/30745362 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005185 |
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