Structural insights into the subtype-selective antagonist binding to the M2 muscarinic receptor

Human muscarinic receptor, M(2) is one of the five subtypes of muscarinic receptors belonging to the family of G protein-coupled receptors. Muscarinic receptors are targets for multiple neurodegenerative diseases. The challenge has been designing subtype selective ligands against one of the five mus...

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Gepubliceerd in:Nat Chem Biol
Hoofdauteurs: Suno, Ryoji, Lee, Sangbae, Maeda, Shoji, Yasuda, Satoshi, Yamashita, Keitaro, Hirata, Kunio, Horita, Shoichiro, Tawaramoto, Maki S., Tsujimoto, Hirokazu, Murata, Takeshi, Kinoshita, Masahiro, Vaidehi, Nagarajan, Yamamoto, Masaki, Kobilka, Brian K, Iwata, So, Kobayashi, Takuya
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6462224/
https://ncbi.nlm.nih.gov/pubmed/30420692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-018-0152-y
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