Risk variants disrupting enhancers of T(H)1 and T(REG) cells in type 1 diabetes

Genome-wide association studies (GWASs) have revealed 59 genomic loci associated with type 1 diabetes (T1D). Functional interpretation of the SNPs located in the noncoding region of these loci remains challenging. We perform epigenomic profiling of two enhancer marks, H3K4me1 and H3K27ac, using prim...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Gao, Peng, Uzun, Yasin, He, Bing, Salamati, Sarah E., Coffey, Julie K. M., Tsalikian, Eva, Tan, Kai
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6462079/
https://ncbi.nlm.nih.gov/pubmed/30910956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1815336116
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