The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins

Mucin domains are densely O-glycosylated modular protein domains that are found in a wide variety of cell surface and secreted proteins. Mucin-domain glycoproteins are known to be key players in a host of human diseases, especially cancer, wherein mucin expression and glycosylation patterns are alte...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Malaker, Stacy A., Pedram, Kayvon, Ferracane, Michael J., Bensing, Barbara A., Krishnan, Venkatesh, Pett, Christian, Yu, Jin, Woods, Elliot C., Kramer, Jessica R., Westerlind, Ulrika, Dorigo, Oliver, Bertozzi, Carolyn R.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2019
Sujets:
PNAS Plus
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6462054/
https://ncbi.nlm.nih.gov/pubmed/30910957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1813020116
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