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Molecular binding mode of PF-232798, a clinical anti-HIV candidate, at chemokine receptor CCR5
The chemokine receptor CCR5 is an important anti-HIV (human immunodeficiency virus) drug target owning to its pivotal role in HIV-1 viral entry as a co-receptor. Here, we present a 2.9 Å resolution crystal structure of CCR5 bound to PF-232798, a second-generation oral CCR5 antagonist currently in ph...
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| Publicado no: | Acta Pharmacol Sin |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6462036/ https://ncbi.nlm.nih.gov/pubmed/29941870 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-018-0054-2 |
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