TRIM17 and TRIM28 antagonistically regulate the ubiquitination and anti-apoptotic activity of BCL2A1

BCL2A1 is an anti-apoptotic member of the BCL-2 family that contributes to chemoresistance in a subset of tumors. BCL2A1 has a short half-life due to its constitutive processing by the ubiquitin–proteasome system. This constitutes a major tumor-suppressor mechanism regulating BCL2A1 function. Howeve...

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Publicado no:Cell Death Differ
Main Authors: Lionnard, Loïc, Duc, Pauline, Brennan, Margs S., Kueh, Andrew J., Pal, Martin, Guardia, Francesca, Mojsa, Barbara, Damiano, Maria-Alessandra, Mora, Stéphan, Lassot, Iréna, Ravichandran, Ramya, Cochet, Claude, Aouacheria, Abdel, Potts, Patrick Ryan, Herold, Marco J., Desagher, Solange, Kucharczak, Jérôme
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461866/
https://ncbi.nlm.nih.gov/pubmed/30042493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0169-5
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