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Trim17-mediated ubiquitination and degradation of Mcl-1 initiate apoptosis in neurons
Short-term proteasome inhibition has been shown to prevent neuronal apoptosis. However, the key pro-survival proteins that must be degraded for triggering neuronal death are mostly unknown. Here, we show that Mcl-1, an anti-apoptotic Bcl-2 family member, is degraded by the proteasome during neuronal...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3554334/ https://ncbi.nlm.nih.gov/pubmed/22976837 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.124 |
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