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Assembly of Human Stem Cell-Derived Cortical Spheroids and Vascular Spheroids to Model 3-D Brain-like Tissues

Human cerebral organoids derived from induced pluripotent stem cells (iPSCs) provide novel tools for recapitulating the cytoarchitecture of human brain and for studying biological mechanisms of neurological disorders. However, the heterotypic interactions of neurovascular units, composed of neurons,...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Song, Liqing, Yuan, Xuegang, Jones, Zachary, Griffin, Kyle, Zhou, Yi, Ma, Teng, Li, Yan
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461701/
https://ncbi.nlm.nih.gov/pubmed/30979929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42439-9
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