Hepatic Autophagy Deficiency Compromises FXR Functionality and Causes Cholestatic Injury

Autophagy is important for hepatic homeostasis, nutrient regeneration and organelle quality control. We investigated the mechanisms by which liver injury occurred in the absence of autophagy function. We found that mice deficient in autophagy due to the lack of Atg7 or Atg5, key autophagy-related ge...

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Bibliografiset tiedot
Julkaisussa:Hepatology
Päätekijät: Khambu, Bilon, Li, Tiangang, Yan, Shengmin, Yu, Changshun, Chen, Xiaoyun, Goheen, Michael, Li, Yong, Lin, Jingmei, Cummings, Oscar W., Lee, Youngmin A., Friedman, Scott, Dong, Zheng, Feng, Gen-Sheng, Wu, Shangwei, Yin, Xiao-Ming
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461497/
https://ncbi.nlm.nih.gov/pubmed/30520052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.30407
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