Targeted disruption of glycogen synthase kinase-3β in cardiomyocytes attenuates cardiac parasympathetic dysfunction in type 1 diabetic Akita mice

Type 1 diabetic Akita mice develop severe cardiac parasympathetic dysfunction that we have previously demonstrated is due at least in part to an abnormality in the response of the end organ to parasympathetic stimulation. Specifically, we had shown that hypoinsulinemia in the diabetic heart results...

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Publicado en:PLoS One
Main Authors: Zhang, Yali, Welzig, Charles M., Haburcak, Marian, Wang, Bo, Aronovitz, Mark, Blanton, Robert M., Park, Ho-Jin, Force, Thomas, Noujaim, Sami, Galper, Jonas B.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2019
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461277/
https://ncbi.nlm.nih.gov/pubmed/30978208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0215213
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