Role of SREBP-1 in the Development of Parasympathetic Dysfunction in the Hearts of Type I Diabetic Akita Mice

Diabetic Autonomic Neuropathy (DAN), a major complication of diabetes mellitus, is characterized in part by impaired cardiac parasympathetic responsiveness. Parasympathetic stimulation of the heart involves activation of an acetylcholine-gated K(+) current, I(KAch), via a (GIRK1)(2)/(GIRK4)(2) K(+)...

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Autors principals: Park, Ho-Jin, Zhang, Yali, Du, Chuang, Welzig, C. Michael, Madias, Christopher, Aronovitz, Mark J., Georgescu, Serban P., Naggar, Isaac, Wang, Bo, Kim, Young-Bum, Blaustein, Robert O., Karas, Richard H., Liao, Ronglih, Mathews, Clayton E., Galper, Jonas B.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2730600/
https://ncbi.nlm.nih.gov/pubmed/19423844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.193995
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