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Costimulatory and coinhibitory immune checkpoint receptors in head and neck cancer: unleashing immune responses through therapeutic combinations

Head and neck squamous cell carcinoma (HNSCC) represents a model of escape from anti-tumor immunity. The high frequency of p53 tumor suppressor loss in HNSCC leads to genomic instability and immune stimulation through the generation of neoantigens. However, the aggressive nature of HNSCC tumors and...

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Vydáno v:Cancers Head Neck
Hlavní autoři: Davis, Ruth J., Ferris, Robert L., Schmitt, Nicole C.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6460794/
https://ncbi.nlm.nih.gov/pubmed/31093342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s41199-016-0013-x
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