Combination central tolerance and peripheral checkpoint blockade unleashes antimelanoma immunity

Blockade of immune checkpoint proteins (e.g., CTLA-4, PD-1) improves overall survival in advanced melanoma; however, therapeutic benefit is limited to only a subset of patients. Because checkpoint blockade acts by “removing the brakes” on effector T cells, the efficacy of checkpoint blockade may be...

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Dades bibliogràfiques
Publicat a:JCI Insight
Autors principals: Bakhru, Pearl, Zhu, Meng-Lei, Wang, Hsing-Hui, Hong, Lee K., Khan, Imran, Mouchess, Maria, Gulati, Ajay S., Starmer, Joshua, Hou, Yafei, Sailer, David, Lee, Sandra, Zhao, Fengmin, Kirkwood, John M., Moschos, Stergios, Fong, Lawrence, Anderson, Mark S., Su, Maureen A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5621898/
https://ncbi.nlm.nih.gov/pubmed/28931755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.93265
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