Combination central tolerance and peripheral checkpoint blockade unleashes antimelanoma immunity

Blockade of immune checkpoint proteins (e.g., CTLA-4, PD-1) improves overall survival in advanced melanoma; however, therapeutic benefit is limited to only a subset of patients. Because checkpoint blockade acts by “removing the brakes” on effector T cells, the efficacy of checkpoint blockade may be...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Bakhru, Pearl, Zhu, Meng-Lei, Wang, Hsing-Hui, Hong, Lee K., Khan, Imran, Mouchess, Maria, Gulati, Ajay S., Starmer, Joshua, Hou, Yafei, Sailer, David, Lee, Sandra, Zhao, Fengmin, Kirkwood, John M., Moschos, Stergios, Fong, Lawrence, Anderson, Mark S., Su, Maureen A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5621898/
https://ncbi.nlm.nih.gov/pubmed/28931755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.93265
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