Combination central tolerance and peripheral checkpoint blockade unleashes antimelanoma immunity

Blockade of immune checkpoint proteins (e.g., CTLA-4, PD-1) improves overall survival in advanced melanoma; however, therapeutic benefit is limited to only a subset of patients. Because checkpoint blockade acts by “removing the brakes” on effector T cells, the efficacy of checkpoint blockade may be...

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Bibliografische gegevens
Gepubliceerd in:JCI Insight
Hoofdauteurs: Bakhru, Pearl, Zhu, Meng-Lei, Wang, Hsing-Hui, Hong, Lee K., Khan, Imran, Mouchess, Maria, Gulati, Ajay S., Starmer, Joshua, Hou, Yafei, Sailer, David, Lee, Sandra, Zhao, Fengmin, Kirkwood, John M., Moschos, Stergios, Fong, Lawrence, Anderson, Mark S., Su, Maureen A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2017
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5621898/
https://ncbi.nlm.nih.gov/pubmed/28931755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.93265
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