Combination central tolerance and peripheral checkpoint blockade unleashes antimelanoma immunity

Blockade of immune checkpoint proteins (e.g., CTLA-4, PD-1) improves overall survival in advanced melanoma; however, therapeutic benefit is limited to only a subset of patients. Because checkpoint blockade acts by “removing the brakes” on effector T cells, the efficacy of checkpoint blockade may be...

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Bibliographic Details
Published in:JCI Insight
Main Authors: Bakhru, Pearl, Zhu, Meng-Lei, Wang, Hsing-Hui, Hong, Lee K., Khan, Imran, Mouchess, Maria, Gulati, Ajay S., Starmer, Joshua, Hou, Yafei, Sailer, David, Lee, Sandra, Zhao, Fengmin, Kirkwood, John M., Moschos, Stergios, Fong, Lawrence, Anderson, Mark S., Su, Maureen A.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5621898/
https://ncbi.nlm.nih.gov/pubmed/28931755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.93265
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