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Costimulatory and coinhibitory immune checkpoint receptors in head and neck cancer: unleashing immune responses through therapeutic combinations

Head and neck squamous cell carcinoma (HNSCC) represents a model of escape from anti-tumor immunity. The high frequency of p53 tumor suppressor loss in HNSCC leads to genomic instability and immune stimulation through the generation of neoantigens. However, the aggressive nature of HNSCC tumors and...

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Bibliographic Details
Published in:Cancers Head Neck
Main Authors: Davis, Ruth J., Ferris, Robert L., Schmitt, Nicole C.
Format: Artigo
Language:Inglês
Published: BioMed Central 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6460794/
https://ncbi.nlm.nih.gov/pubmed/31093342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s41199-016-0013-x
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