Inhibition of HMGB1/RAGE-mediated endocytosis by HMGB1 antagonist box A, anti-HMGB1 antibodies, and cholinergic agonists suppresses inflammation

BACKGROUND: Extracellular high mobility group box 1 protein  (HMGB1) serves a central role in inflammation as a transporter protein, which binds other immune-activating molecules that are endocytosed via the receptor for advanced glycation end-products (RAGE). These pro-inflammatory complexes are ta...

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Bibliographic Details
Published in:Mol Med
Main Authors: Yang, Huan, Liu, Hui, Zeng, Qiong, Imperato, Gavin H., Addorisio, Meghan E., Li, Jianhua, He, Mingzhu, Cheng, Kai Fan, Al-Abed, Yousef, Harris, Helena E., Chavan, Sangeeta S., Andersson, Ulf, Tracey, Kevin J.
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6460792/
https://ncbi.nlm.nih.gov/pubmed/30975096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s10020-019-0081-6
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