Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease

BACKGROUND: Based on epidemiological and experimental studies, type 2 diabetes mellitus (T2DM), especially insulin resistance that comprises the core mechanism of T2DM, has been recognized as a significant risk factor for Alzheimer’s disease (AD). Studies in humans and diabetic AD model mice have in...

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Udgivet i:Mol Neurodegener
Main Authors: Wakabayashi, Tomoko, Yamaguchi, Kazuki, Matsui, Kentaro, Sano, Toshiharu, Kubota, Tetsuya, Hashimoto, Tadafumi, Mano, Ayako, Yamada, Kaoru, Matsuo, Yuko, Kubota, Naoto, Kadowaki, Takashi, Iwatsubo, Takeshi
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6460655/
https://ncbi.nlm.nih.gov/pubmed/30975165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-019-0315-7
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