Enriched power of disease-concordant twin-case-only design in detecting interactions in genome-wide association studies

Genetic interaction is a crucial issue in the understanding of functional pathways underlying complex diseases. However, detecting such interaction effects is challenging in terms of both methodology and statistical power. We address this issue by introducing a disease-concordant twin-case-only desi...

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Udgivet i:Eur J Hum Genet
Main Authors: Li, Weilong, Baumbach, Jan, Mohammadnejad, Afsaneh, Brasch-Andersen, Charlotte, Vandin, Fabio, Korbel, Jan O., Tan, Qihua
Format: Artigo
Sprog:Inglês
Udgivet: Springer International Publishing 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6460588/
https://ncbi.nlm.nih.gov/pubmed/30659261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41431-018-0320-2
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