Spatial Clustering of Receptors and Signaling Molecules Regulates NK Cell Response to Peptide Repertoire Changes

Natural Killer (NK) cell activation requires integration of inhibitory and activating signaling. Inhibitory signals are determined by members of the killer cell immunoglobulin-like receptor (KIR) family, which have major histocompatibility complex (MHC) class I ligands. Loss of this inhibitory signa...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Mbiribindi, Berenice, Mukherjee, Sayak, Wellington, Dannielle, Das, Jayajit, Khakoo, Salim I.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6460049/
https://ncbi.nlm.nih.gov/pubmed/31024524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00605
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