Evaluation of a noncanonical Cys40‐Cys55 disulfide linkage for stabilization of single‐domain antibodies

Incorporation of noncanonical disulfide linkages into single‐domain antibodies (sdAbs) has been shown to enhance thermostability and other properties. Here, we evaluated the effects of introducing a novel disulfide linkage formed between Cys residues at IMGT positions 40 and 55 on the melting temper...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Protein Sci
Asıl Yazarlar: Kim, Dae Young, Kandalaft, Hiba, Hussack, Greg, Raphael, Shalini, Ding, Wen, Kelly, John F., Henry, Kevin A., Tanha, Jamshid
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley & Sons, Inc. 2019
Konular:
Full‐Length Papers
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6459990/
https://ncbi.nlm.nih.gov/pubmed/30803088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3595
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