Evaluation of a noncanonical Cys40‐Cys55 disulfide linkage for stabilization of single‐domain antibodies

Incorporation of noncanonical disulfide linkages into single‐domain antibodies (sdAbs) has been shown to enhance thermostability and other properties. Here, we evaluated the effects of introducing a novel disulfide linkage formed between Cys residues at IMGT positions 40 and 55 on the melting temper...

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Publicat a:Protein Sci
Autors principals: Kim, Dae Young, Kandalaft, Hiba, Hussack, Greg, Raphael, Shalini, Ding, Wen, Kelly, John F., Henry, Kevin A., Tanha, Jamshid
Format: Artigo
Idioma:Inglês
Publicat: John Wiley & Sons, Inc. 2019
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Full‐Length Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6459990/
https://ncbi.nlm.nih.gov/pubmed/30803088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3595
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