Multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) ranks fourth among cancer-related deaths in China due to the lack of actionable molecules. We performed whole-exome and T-cell receptor (TCR) repertoire sequencing on multi-regional tumors, normal tissues and blood samples from 39 ESCC patients. The data rev...

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Udgivet i:Nat Commun
Main Authors: Yan, Ting, Cui, Heyang, Zhou, Yong, Yang, Bin, Kong, Pengzhou, Zhang, Yingchun, Liu, Yiqian, Wang, Bin, Cheng, Yikun, Li, Jiayi, Guo, Shixing, Xu, Enwei, Liu, Huijuan, Cheng, Caixia, Zhang, Ling, Chen, Ling, Zhuang, Xiaofei, Qian, Yu, Yang, Jian, Ma, Yanchun, Li, Hongyi, Wang, Fang, Liu, Jing, Liu, Xuefeng, Su, Dan, Wang, Yan, Sun, Ruifang, Guo, Shiping, Li, Yaoping, Cheng, Xiaolong, Liu, Zhihua, Zhan, Qimin, Cui, Yongping
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6459928/
https://ncbi.nlm.nih.gov/pubmed/30975989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09255-1
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