Elevated DHODH expression promotes cell proliferation via stabilizing β-catenin in esophageal squamous cell carcinoma

As a key enzyme in de novo pyrimidine biosynthesis, the expression level of dihydroorotate dehydrogenase (DHODH) has been reported to be elevated in various types of malignant tumors and its tumor-promoting effect was considered to relate to its pyrimidine synthesis function. Here, we revealed one i...

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Udgivet i:Cell Death Dis
Main Authors: Qian, Yu, Liang, Xiao, Kong, Pengzhou, Cheng, Yikun, Cui, Heyang, Yan, Ting, Wang, Jinghao, Zhang, Ling, Liu, Yiqian, Guo, Shiping, Cheng, Xiaolong, Cui, Yongping
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7566478/
https://ncbi.nlm.nih.gov/pubmed/33060568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03044-1
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