Structural analyses of NudT16–ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins

ADP-ribosylation is a post-translational modification that occurs on chemically diverse amino acids, including aspartate, glutamate, lysine, arginine, serine and cysteine on proteins and is mediated by ADP-ribosyltransferases, including a subset commonly known as poly(ADP-ribose) polymerases. ADP-ri...

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Publicado no:Sci Rep
Main Authors: Thirawatananond, Puchong, McPherson, Robert Lyle, Malhi, Jasmine, Nathan, Sara, Lambrecht, Michael J., Brichacek, Matthew, Hergenrother, Paul J., Leung, Anthony K. L., Gabelli, Sandra B.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6459841/
https://ncbi.nlm.nih.gov/pubmed/30976021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-39491-w
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