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Protective Effects of Activated Myofibroblasts in the Pressure-Overloaded Myocardium Are Mediated Through Smad-Dependent Activation of a Matrix-Preserving Program
RATIONALE: The heart contains abundant interstitial and perivascular fibroblasts. Traditional views suggest that, under conditions of mechanical stress, cytokines, growth factors and neurohumoral mediators stimulate fibroblast activation, inducing extracellular matrix protein synthesis, and promotin...
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| Publié dans: | Circ Res |
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| Auteurs principaux: | , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6459716/ https://ncbi.nlm.nih.gov/pubmed/30686120 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.118.314438 |
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